Transient Myeloproliferative Disorder and Acute Myeloid Leukemia in Down Syndrome
نویسندگان
چکیده
منابع مشابه
Analysis of GATA1 mutations in Down syndrome transient myeloproliferative disorder and myeloid leukemia.
Children with Down syndrome (DS) up to the age of 4 years are at a 150-fold excess risk of developing myeloid leukemia (ML-DS). Approximately 4%-5% of newborns with DS develop transient myeloproliferative disorder (TMD). Blast cell structure and immunophenotype are similar in TMD and ML-DS. A mutation in the hematopoietic transcription factor GATA1 is present in almost all cases. Here, we show ...
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1Department of Pediatrics, Hirosaki University Graduate School of Medicine, Hirosaki, Japan; 2Department of Hematology/Oncology, Gunma Children’s Medical Center, Gunma, Japan; 3Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan; 4Department of Pediatrics, Graduate School of Medicine, University of Toyama, Toyama, Japan; 5Department of Pediatrics, Kagoshima Ci...
متن کاملDown syndrome and GATA1 mutations in transient abnormal myeloproliferative disorder: mutation classes correlate with progression to myeloid leukemia.
Twenty percent to 30% of transient abnormal myelopoiesis (TAM) observed in newborns with Down syndrome (DS) develop myeloid leukemia of DS (ML-DS). Most cases of TAM carry somatic GATA1 mutations resulting in the exclusive expression of a truncated protein (GATA1s). However, there are no reports on the expression levels of GATA1s in TAM blasts, and the risk factors for the progression to ML-DS ...
متن کاملTransient Myeloproliferative Disorder in Neonate with Suspected Down Syndrome
A female with suspected Down syndrome was born by vaginal delivery at 37 weeks 2 days’ gestation to a mother with a history of Type A2 gestational diabetes mellitus. Routine prenatal testing consisted of a non-invasive screening test for aneuploidy. Results, presented in Table 1, indicated an aneuploidy for trisomy of chromosome 21, indicating an increased risk for Down syndrome. Prenatal confi...
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adhesion and enhance mobility. We therefore propose that our results reflect an impaired ability of the more adhesive cd34 / cells to cross intact endothelial barriers en route to BM stem cell niches (Figure 1E). Conversely, irradiation-induced vascular permeability facilitates migration of cd34 / HSCs into subvascular spaces, thereby explaining their favorable competition with wt cells for eng...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2001
ISSN: 0002-9173,1943-7722
DOI: 10.1309/xref-c9t2-6u0a-4edt